Proposed mechanism of tardive dyskinesia [TD] and dopamine receptor hypersensitivity

  • 1Dopamine Signaling

    Dopamine goes through a recycling process where it is transported back into the presynaptic neurons by the dopamine transporter (DAT) and packaged for later use.1*

  • 2Dopamine Hypersensitivity

    The hypersensitivity of postsynaptic dopamine D2 receptors in TD may occur after exposure to DRBAs.2 It is hypothesized that this hypersensitivity in the nigrostriatal pathway manifests in the signs of TD.1

  • 1Dopamine Signaling

    Dopamine goes through a recycling process where it is transported back into the presynaptic neurons by the dopamine transporter (DAT) and packaged for later use.1*

  • 2Dopamine Hypersensitivity

    The hypersensitivity of postsynaptic D2 receptors in TD may occur after exposure to DRBAs.2 It is hypothesized that this hypersensitivity in the nigrostriatal pathway manifests in the signs of TD.1

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References: 1. Stahl SM. Essential Psychopharmacology Online. Based on: Stahl SM. Stahl’s Essential Psychopharmacology. 4th ed. Cambridge, UK: Cambridge University Press; 2013. http://stahlonline.cambridge.org/essential_4th_chapter.jsf?page=chapter5_introduction.htm&name=Chapter%205&title=Conventional%20antipsychotics#c02598-5-1. Accessed March 14, 2016. 2. Sayers AC, Bürki HR, Ruch W, et al. Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias: effects of clozapine, haloperidol, loxapine and chlorpromazine. Psychopharmacologia. 1975;41(2):97-104.

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